IndraLab

Statements

FOXO1 inhibits SCN5A. 4 / 4
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"XREF_BIBR Accordingly, FoXO1 expression in HL-1 cells decreased SCN5A promoter activity whereas FoxO1 siRNA increased sodium protein in these cells XREF_BIBR."
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"Expression of Foxo1 significantly suppressed SCN5a promoter activity (p < 0.01), and the suppression was Foxo1 dose dependent (XREF_FIG)."
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"Foxo1 Negatively Regulates SCN5a Promoter Activity."
22400069
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"Both NF-kappaB and FoxO1 suppress SCN5a promoter activity, leading to the down-regulation of Na V 1.5 expression [XREF_BIBR, XREF_BIBR], indicating that these two signaling pathways play important roles in the regulation of Na + channel activity in heart diseases."
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