IndraLab

Statements

FOXO1 inhibits SCN5A. 5 / 5
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"For instance, Benzhi Cai et al. [XREF_BIBR], reported that deletion of FOXO1 in heart caused an increment in myocardial Na+ load by augmenting NaV1.5, a principle alpha subunit of the cardiac sodium ion channel and Na+ channel subunit beta3 mRNA and resulted in shortening of QRS complex significantly, proposing that FOXO1 is facilitating the modulation of sodium channel in ischemic cardiomyopathy."
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"Foxo1 Negatively Regulates SCN5a Promoter Activity."
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"Both NF-kappaB and FoxO1 suppress SCN5a promoter activity, leading to the down-regulation of Na V 1.5 expression [XREF_BIBR, XREF_BIBR], indicating that these two signaling pathways play important roles in the regulation of Na + channel activity in heart diseases."
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"Expression of Foxo1 significantly suppressed SCN5a promoter activity (p < 0.01), and the suppression was Foxo1 dose dependent (XREF_FIG)."
22400069
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"XREF_BIBR Accordingly, FoXO1 expression in HL-1 cells decreased SCN5A promoter activity whereas FoxO1 siRNA increased sodium protein in these cells XREF_BIBR."
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