IndraLab

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reach
"In addition, USP4 suppressed IFN response and antigen presentation process, thus impeding the antitumor immune response in CRC cells and a syngeneic mouse model."
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"In the current study, we demonstrated that USP4 suppresses the IFN response and antigen presentation process in CRC cells, suggesting that USP4 negatively regulates cytosolic PRR-mediated signaling an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, knockdown of USP4 significantly elevated the gene expression levels of the MHC-I-dependent antigen processing and presentation pathway in CRC cells ( Fig. 3 C–D)."
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