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USP22 inhibits apoptotic process. 64 / 69
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"Downregulation of USP22 raised the sensitivity of PC cells to cisplatin , reduced the levels of stem cell markers , reduced the tumor sphere formation and migration , and promoted apoptosis ."
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"As a consequence, gain of USP22 functions promotes cell cycle progression and inhibits cell apoptosis, leading to cancer cell hyper-proliferation and tumorigenesis."
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"Also, USP22 silencing promotes apoptosis and cell cycle arrest in human brain gliomas."
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"Silencing USP22 promoted Bel/Fu cell apoptosis, but had no effect on cell cycle progression."
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"USP22 Silencing Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest in NSCLC Cells."
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"As expected, overexpression of USP22 in PC9 cells significantly reduced apoptosis (0.7667 +/- 0.06667% vs. 2.267 +/- 0.5044%, p < 0.05, Fig. 2 D)."
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"Therefore, these data suggest that USP22 decreases cell arrest in G1 phase and reduces apoptosis of EGFR-mutant lung ADC cells in vitro."
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"Overexpression of USP22 in macrophages inhibits foam cell formation, inflammation, and macrophage apoptosis."
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"Finally, we observed that USP22 inhibited macrophage early apoptosis under basal and inflammatory conditions (Fig. 3H–J)."
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"We next explored the pathways by which USP22 silencing promoted HepG2 cell apoptosis."
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"In retinoblastoma, the depletion of USP22 has been shown to induce cancer cell apoptosis by suppressing the TERT/P53 signal pathway ."
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"Furthermore, USP22 knockout significantly impaired non homologous DNA damage repair capacity, enhanced cisplatin and irradiation induced apoptosis in these cells."
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"RNA interference mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest."
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"Additionally, by deubiquitinating Sirt1, the increased expression of USP22 decreased the frequency of p53-dependent apoptosis and oxidative response (Figures 5, 6)."
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"RNA interference mediated USP22 gene silencing induced apoptosis of human brain glioma cells."
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"Taken together, these findings strongly indicate that USP22 silencing triggered the mitochondrial apoptosis pathway that is associated with caspase 3 activation in HCC cells."
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"In terms of inhibitors, 4′-O-tetrahydropyranyl-adriamycin (THP; pirarubicin) partially reduces USP22 expression and promotes HeLa cell apoptosis [ 92 ]."
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"USP22 can be inhibited by shRNA, activates the p53 pathway in tumours and downregulates MDMX protein, thereby inducing apoptosis in NSCLC cells (9)."
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"Previous studies have reported that USP22 gene silencing induced apoptosis of bladder and colorectal cancer cells."
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"Our results demonstrated that USP22 silencing suppressed cell growth and induced cell apoptosis."
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"Accordingly, USP22 downregulation also attenuated cerebral I/R-induced oxidative stress, inflammation, and cell apoptosis in mice, thereby reducing nerve injury and neurological dysfunction [20]."
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"USP22 depletion promotes in vitro GC cell apoptosis."
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"Studies have demonstrated that USP22 directly interacts with SIRT1, activating the AKT/GSK-3β/multidrug resistance-associated protein 1 (MRP1) pathway, thereby enhancing 5-Fu efflux and reducing 5-Fu-induced apoptosis in HCC cells [124]."
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"The results demonstrate that inhibition of USP22 expression can induce apoptosis in Sao-2 cells."
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"In addition, since we observed in vivo that overexpression of USP22 in macrophages reduced the accumulation of apoptotic cells in plaques and that our in vitro experiments also revealed that USP22 reduced macrophage apoptosis under both basal and inflammatory conditions."
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"Genetic USP22 suppression inhibits cancer cell growth and induces apoptosis ."
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"In the rescue experiment, the overexpression of JMJD8 could reduce the apoptosis induced by USP22 knockdown."
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"Importantly, overexpression of MDMX reversed USP22 silencing, induced p53 activation, growth inhibition, cell cycle arrest and apoptosis in A549 cells (XREF_FIG B-E)."
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"In vitro assays showed that USP22 depletion suppressed ATC cell survival and proliferation by decreasing Rb phosphorylation and cyclin D2, inactivating Akt, and simultaneously upregulating Rb; USP22 silencing restrained cell migration and invasion by inhibiting epithelial-mesenchymal transition; USP22 knockdown promoted mitochondrion- mediated and caspase dependent apoptosis by upregulating Bax and Bid and promoting caspase-3 activation."
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"In addition, caspase-3 was activated, indicating that caspase associated apoptosis was induced by USP22 silencing."
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"Our in vitro and in vivo studies showed that USP22 silencing by shRNA inhibits proliferation and induces cell cycle arrest and apoptosis in human NSCLC cells in vitro and curbs human NSCLC tumor growth in a mouse xenograft model in vivo."
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"As a novel de-ubiquitinating enzyme with ubiquitin hydrolase activity, USP22 might inhibit apoptosis in HCC by activating the BMI-1-mediated PcG stem cell pathway [ xref ]."
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"As a novel de-ubiquitinating enzyme with ubiquitin hydrolase activity, USP22 might inhibit apoptosis in HCC by activating the BMI-1-mediated PcG stem cell pathway [XREF_BIBR]."
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"Our previous studies have confirmed that defects in USP22 can not only cause cell cycle arrest in G0/G1 phase, but also inhibit apoptosis and promote tumor cell proliferation [XREF_BIBR]."
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"USP22 inhibition restores cisplatin sensitivity in cisplatin-resistant lung cancer cells.Cisplatin can induce cell death by activating mitochondrial apoptosis."
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"USP22 knockdown promotes apoptosis of ATC cells in vitro."
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"Silencing of USP22 promotes human retinoblastoma cell apoptosis by inhibiting TERT and P53 pathway 36."
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"USP22 upregulation can overcome cisplatin-induced cycle arrest and inhibit apoptosis (56)."
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"USP22 can also suppress apoptosis and promote cell proliferation by antagonizing p53 function through the regulation of SIRT1[29,30]."
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"After treating with 1.25 μmol/L oxaliplatin for 48 h, USP22 overexpression can inhibit SW480 cells apoptosis."
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"We then tested whether USP22 expression inhibits cell apoptosis upon DNA damage."
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"Moreover, USP22 knockdown induces apoptosis in GC cells."
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"However, overexpression of USP22 or BMI1 suppressed the upward trend of apoptosis in GSCs ( Figs."
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"Since Sirt1 is a suppressor for p53 functions, it is possible that USP22 promotes cell proliferation and suppresses apoptosis through regulation of Sirt1 to antagonize p53 function."
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"Conclusively, these results suggested that overexpression of USP22 inhibited 5-FU-induced cell apoptosis and promoted ADR efflux in HCC cells."
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"The knockdown of ubiquitin-specific protease USP22 causes gastric cancer cell apoptosis via a reduction in YAP protein levels [173]."
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"It has been reported that USP22 silencing induced apoptosis of bladder [XREF_BIBR], colorectal [XREF_BIBR], and glioma [XREF_BIBR] cancer cells."
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"Consistently, in the current study, USP22 knockdown markedly induced ATC cell apoptosis, as evidenced by the results of flow cytometry, TUNEL, and nucleosomal enrichment factor assays."
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"In the attempt to explore the mechanisms by which USP22 silencing leads to ATC cell apoptosis, we found that the proapoptotic members of Bcl-2 family proteins, Bid and Bax, were upregulated in response to USP22 knockdown, consistent with increased activation of caspase-3."
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"Loss of USP22 expression has also been shown to increase apoptosis in several cancer cell lines , including the colorectal cell line HCT116 ( Xu et al , 2012 ) ."
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"USP22 suppresses cell apoptosis by inhibiting p53 functions in a SIRT1-dependent manner, while its anti-apoptotic effects are required for mouse embryonic development."
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"Consistent with our finding that USP22 knockdown promotes cell apoptosis through destabilizing Sirt1, a dramatic reduction in Sirt1 protein levels was detected in usp22 null MEFs ( Figure 6 F)."
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"Moreover, knockdown of either USP22 or Sirt1 promoted etoposide-induced cell apoptosis, which is further enhanced by a combined Sirt1/USP22 knockdown ( Figure 5 I)."
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"Multiple studies show that USP22 silencing increases apoptosis in both mouse and human embryonic fibroblasts, as well as in multiple cancer cell lines, including colorectal and brain glioma cell lines [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Conversely, USP22 overexpression in HeLa cells was shown to attenuate apoptosis induced by trichostatin A (histone deacetylase inhibitor) treatment [XREF_BIBR]."
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"Therefore in multiple cancer cell lines, increased USP22 expression attenuates apoptosis."
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"USP22 inhibits cell apoptosis while promoting cell cycle transition in gastric cancer cells."
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"The TUNEL assay showed that USP22 overexpression significantly suppressed apoptosis in SGC7901 cells, whereas silencing enhanced apoptosis in AGS cells (Fig. 3a)."
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"Hence, in multiple cancer cell lines, increased USP22 expression attenuates apoptosis and promotes treatment resistance."
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"In addition, USP22/SIRT1-regulated mitochondrial respiration can affect liver steatosis, and the silencing of USP22 in diabetic rats confers a similar protective effect against high glucose-induced ap[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 upregulation may thus inhibit apoptosis and stimulate autophagy in response to treatment with DNA damaging agents or targeted inhibitors to promote resistance to chemotherapy in cancer patients."
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"Furthermore, USP22 stabilizes SIRT1 activity through deubiquitination, thereby promoting SIRT1's ability to deacetylate p53 and inhibit apoptosis (67)."
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"In retinoblastoma, USP22 depletion induces cancer cell apoptosis by inhibiting the TERT/P53 signaling pathway (89)."
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"These results suggest that USP22 promotes gastric cancer growth while inhibiting apoptosis in vivo."
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