IndraLab

Statements

USP22 inhibits apoptotic process. 42 / 47
| 2 39 1
reach
"USP22 Silencing Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest in NSCLC Cells."
25547493
reach
"These results suggest that USP22 promotes gastric cancer growth while inhibiting apoptosis in vivo."
32063746
reach
"Silencing of USP22 promotes human retinoblastoma cell apoptosis by inhibiting TERT and P53 pathway 36."
33568633
reach
"In retinoblastoma, the depletion of USP22 has been shown to induce cancer cell apoptosis by suppressing the TERT/P53 signal pathway ."
34660907
reach
"As a consequence, gain of USP22 functions promotes cell cycle progression and inhibits cell apoptosis, leading to cancer cell hyper-proliferation and tumorigenesis."
27030811
reach
"Importantly, overexpression of MDMX reversed USP22 silencing, induced p53 activation, growth inhibition, cell cycle arrest and apoptosis in A549 cells (XREF_FIG B-E)."
25547493
reach
"Previous studies have reported that USP22 gene silencing induced apoptosis of bladder and colorectal cancer cells."
23599781
reach
"RNA interference mediated USP22 gene silencing induced apoptosis of human brain glioma cells."
23599781
reach
"USP22 depletion promotes in vitro GC cell apoptosis."
31689236
reach
"Taken together, these findings strongly indicate that USP22 silencing triggered the mitochondrial apoptosis pathway that is associated with caspase 3 activation in HCC cells."
25909224
reach
"Therefore, these data suggest that USP22 decreases cell arrest in G1 phase and reduces apoptosis of EGFR-mutant lung ADC cells in vitro."
29981430
reach
"USP22 inhibits cell apoptosis while promoting cell cycle transition in gastric cancer cells."
32063746
reach
"Conclusively, these results suggested that overexpression of USP22 inhibited 5-FU-induced cell apoptosis and promoted ADR efflux in HCC cells."
28417539
eidos
"Downregulation of USP22 raised the sensitivity of PC cells to cisplatin , reduced the levels of stem cell markers , reduced the tumor sphere formation and migration , and promoted apoptosis ."
35623308
reach
"The knockdown of ubiquitin-specific protease USP22 causes gastric cancer cell apoptosis via a reduction in YAP protein levels [173]."
33582842
reach
"Silencing USP22 promoted Bel/Fu cell apoptosis, but had no effect on cell cycle progression."
28445968
reach
"We next explored the pathways by which USP22 silencing promoted HepG2 cell apoptosis."
25909224
reach
"In vitro assays showed that USP22 depletion suppressed ATC cell survival and proliferation by decreasing Rb phosphorylation and cyclin D2, inactivating Akt, and simultaneously upregulating Rb; USP22 silencing restrained cell migration and invasion by inhibiting epithelial-mesenchymal transition; USP22 knockdown promoted mitochondrion- mediated and caspase dependent apoptosis by upregulating Bax and Bid and promoting caspase-3 activation."
27145278
eidos
"Loss of USP22 expression has also been shown to increase apoptosis in several cancer cell lines , including the colorectal cell line HCT116 ( Xu et al , 2012 ) ."
33369872
reach
"After treating with 1.25 μmol/L oxaliplatin for 48 h, USP22 overexpression can inhibit SW480 cells apoptosis."
34954996
reach
"USP22 knockdown promotes apoptosis of ATC cells in vitro."
27145278
reach
"RNA interference mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest."
23599781
sparser
"As a novel de-ubiquitinating enzyme with ubiquitin hydrolase activity, USP22 might inhibit apoptosis in HCC by activating the BMI-1-mediated PcG stem cell pathway [ xref ]."
25909224
reach
"Moreover, USP22 knockdown induces apoptosis in GC cells."
31689236
reach
"Accordingly, USP22 downregulation also attenuated cerebral I/R-induced oxidative stress, inflammation, and cell apoptosis in mice, thereby reducing nerve injury and neurological dysfunction [20]."
34824671
reach
"In the attempt to explore the mechanisms by which USP22 silencing leads to ATC cell apoptosis, we found that the proapoptotic members of Bcl-2 family proteins, Bid and Bax, were upregulated in response to USP22 knockdown, consistent with increased activation of caspase-3."
27145278
reach
"Our previous studies have confirmed that defects in USP22 can not only cause cell cycle arrest in G0/G1 phase, but also inhibit apoptosis and promote tumor cell proliferation [XREF_BIBR]."
32294625
reach
"Also, USP22 silencing promotes apoptosis and cell cycle arrest in human brain gliomas."
26613948
reach
"Our in vitro and in vivo studies showed that USP22 silencing by shRNA inhibits proliferation and induces cell cycle arrest and apoptosis in human NSCLC cells in vitro and curbs human NSCLC tumor growth in a mouse xenograft model in vivo."
25547493
reach
"Multiple studies show that USP22 silencing increases apoptosis in both mouse and human embryonic fibroblasts, as well as in multiple cancer cell lines, including colorectal and brain glioma cell lines [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
29210986
reach
"Hence, in multiple cancer cell lines, increased USP22 expression attenuates apoptosis and promotes treatment resistance."
29210986
reach
"In addition, caspase-3 was activated, indicating that caspase associated apoptosis was induced by USP22 silencing."
25909224
reach
"Our results demonstrated that USP22 silencing suppressed cell growth and induced cell apoptosis."
25909224
reach
"As expected, overexpression of USP22 in PC9 cells significantly reduced apoptosis (0.7667 +/- 0.06667% vs. 2.267 +/- 0.5044%, p < 0.05, Fig. 2 D)."
29981430
reach
"Conversely, USP22 overexpression in HeLa cells was shown to attenuate apoptosis induced by trichostatin A (histone deacetylase inhibitor) treatment [XREF_BIBR]."
29210986
reach
"As a novel de-ubiquitinating enzyme with ubiquitin hydrolase activity, USP22 might inhibit apoptosis in HCC by activating the BMI-1-mediated PcG stem cell pathway [XREF_BIBR]."
25909224
reach
"It has been reported that USP22 silencing induced apoptosis of bladder [XREF_BIBR], colorectal [XREF_BIBR], and glioma [XREF_BIBR] cancer cells."
27145278
reach
"Furthermore, USP22 knockout significantly impaired non homologous DNA damage repair capacity, enhanced cisplatin and irradiation induced apoptosis in these cells."
31842906
reach
"Consistently, in the current study, USP22 knockdown markedly induced ATC cell apoptosis, as evidenced by the results of flow cytometry, TUNEL, and nucleosomal enrichment factor assays."
27145278
reach
"USP22 upregulation may thus inhibit apoptosis and stimulate autophagy in response to treatment with DNA damaging agents or targeted inhibitors to promote resistance to chemotherapy in cancer patients."
29210986
reach
"Silencing USP22 reduced the stemness and proliferation of GSCs, and increased its apoptosis in response to hypoxia."
32070708
reach
"The TUNEL assay showed that USP22 overexpression significantly suppressed apoptosis in SGC7901 cells, whereas silencing enhanced apoptosis in AGS cells (Fig. 3a)."
32063746