IndraLab
Statements
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"XREF_FIG A, knockdown of USP22 by shRNA inhibited the AKT and MRP1 pathway compared with control shRNA cells and wild-type cells."
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"Previous study also showed that USP22 promotes cell cycle progression by positively regulating the PI3K and Akt pathway [XREF_BIBR]."
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"USP22 overexpression in gastric cancer cells induces the upregulation of SOS1 and activation of the RAS/ERK and PI3K/AKT pathways."
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"Western blot analysis showed that USP22 overexpression also induced activation of the RAS and ERK and PI3K and AKT pathways in SGC7901 cells and xenograft tumor tissues."
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"Previous studies have confirmed that USP22 can promote the biological process of NSCLC cells by regulating BMI-1 and AKT signaling pathway [XREF_BIBR]."
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"These results suggest that USP22 downregulation inhibits OS cells by suppressing the PI3K and Akt pathway."
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"We observed that USP22 could positively regulate the AKT pathway in a SIRT1 dependent manner."
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"Similarly, overexpression of USP22 in BEL/7402 cells activated the AKT and MRP1 pathway."
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"Western blot analysis showed that USP22 overexpression also induced activation of the RAS/ERK and PI3K/AKT pathways in SGC7901 cells and xenograft tumor tissues."
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"Moreover, SIRT1 deficiency attenuated USP22 induced activation of the AKT and MRP1 pathway in BEL7402 cells, suggesting that USP22 regulated the AKT and MRP1 pathway in a SIRT1 dependent manner."