IndraLab

Statements

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"In the present study, we wished to test the hypothesis that sodium salicylate, which inhibits IKKbeta, prevents hepatic insulin resistance caused by short-term elevation of FFA."
17951543
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"However, it has been shown that salicylate may reverse TNF-alpha-induced insulin resistance independently of IKK-2 and NF-kappaB inhibition [XREF_BIBR]."
20820848
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"Clinical studies have found that Salsalate, a prodrug of salicylate which suppresses inflammation, attenuates IKKbeta and NF-kappaB activity, improves glycemic control in patients with type-2 diabetes, [XREF_BIBR] and alleviates IR."
28025032
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"High concentrations of sodium salicylate are known to mediate its anti-inflammatory property by inhibiting the cellular kinase IKK-beta, as opposed to working through its classical target cyclooxygenase (COXs) [XREF_BIBR]."
25874611
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"Yuan et al. [XREF_BIBR] demonstrated that reduced signaling through the IKK-beta pathway inhibition by sodium salicylate in obese mice is accompanied by improved insulin sensitivity."
27034691
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"Recently, sodium salicylate and aspirin have been shown to inhibit activation of the transcription factor NF-kappaB by preventing IKK-beta from degradation."
25120374
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"Here we demonstrate that the anti-inflammatory agents aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo."
9817203
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"Sulindac [75], aspirin and salicylate [76] specifically inhibit IkKB kinase activity, and sanguinarine has also been shown to inhibit NFkB activation at the level of IkB phosphorylation [77]."
12419552
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"It has been shown that aspirin, as well as sodium salicylate, inhibits IKK-beta activity in vitro at millimolar concentration [XREF_BIBR] by binding to IKK-beta, thus, competing with ATP for the binding to the kinase, an event necessary to phosphorylate IkB [XREF_BIBR, XREF_BIBR]."
24281340
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"In particular, salicylate is known to inhibit the activity of IKKbeta, and pretreatment of salicylate in lipid infused rats rescues glucose tolerance back to similar levels seen in control rats when compared with lipid infusion alone [XREF_BIBR]."
20798864
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"Insulin resistance was improved by systemic neutralization of IL-6 or salicylate inhibition of IKK-beta."
15685173
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"Salicylate inhibits IKKbeta, to prevent the deleterious effects of excess FFA on insulin signaling and action [XREF_BIBR, XREF_BIBR]."
27128935
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"To support this finding, inhibition of IKKbeta by salicylate was effective in ameliorating inflammation mediated insulin resistance."
23761785
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"Whereas sulfasalazine was found to inhibit both IKKalpha and IKKbeta, aspirin and sodium salicylate were reported to specifically inhibit IKKbeta."
12110242
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"We hypothesized that sodium salicylate would reduce IKKbeta, leading to reduced TNFalpha and improved insulin signaling in the BBZDR and Wor obese rat model of type 2 diabetes."
25874611
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"Yin et al. subsequently demonstrated that salicylate specifically inhibits IKKbeta activity in cell lines in vivo and when the agent is added to the kinase in vitro [XREF_BIBR]."
28718829
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"Salicylic acid and SP600125 partially inhibited IKKbeta and JNK, respectively, which indicated distinct roles for these two kinases in the phosphorylation of IRS1 at the two serine sites."
16896943
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"Salicylate also dramatically inhibited IKKbeta and NF-kappaB activation evoked by PA stimulation."
22766331
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"In vitro, salicylate treatment comparably inhibited the kinase activity of overexpressed IKKalpha and IKKbeta and also decreased p38 kinase activity."
10753891