IndraLab

Statements

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"We observed a decrease in the promoter activity for the fragments larger than −358 bp, which suggests the existence of repressor-binding sequences in these regions.These results suggest that the −237 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, ATXN3 has been shown to modulate transcription factor and repressor degradation by directly altering ubiquitin chains attached to such proteins [XREF_BIBR, XREF_BIBR]."
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"The lack of ATXN3 leads to abnormalities in nuclear and nucleolar morphology, alters DNA replication timing and increases transcription."
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"On the contrary, the expression levels of most chloroplast RNA editing sites‐containing genes are significantly changed in the sca3‐2 mutant (Figure 7A–D) and the editing efficiency of nine RNA editing sites are also altered in the sca3‐2 mutant (Figure 2B,C), suggesting that the editing defects in the sca3‐2 mutant were caused by the mutation in RPOTp itself rather than indirectly caused by the compromised chloroplast gene transcription."
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"As P53 has known functions in cycle arrest and apoptosis, this indicates that expression of atxn3 polyQ repeats induces selective transcription and expression of p53 target genes and promotes p53 dependent apoptosis in the CNS of zebrafish [XREF_BIBR]."
| PMC
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"Mechanistically, ATXN3 was identified as a bona fide deubiquitinase for ZEB1, a key EMT-inducing transcription factor, in GBM cells."
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