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Barium(2+) inhibits NLRP3. 4 / 4
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"We previously showed that BA significantly inhibited the activation of NF-kappaB and the NLRP3 inflammasome during H. parasuis infection in piglet primary mononuclear phagocyte 34."
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"Earlier studies by our group showed that BA can suppress the NLRP3 inflammasome pathway under LPS stimulation [11], and it also has anti-inflammatory activity via NF-κB and NLRP3 inflammasome signaling evoked by HPS in PMNP [4]."
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"In our earlier study, we demonstrated that BA could inhibit the activation of the NF-κB and NLRP3 inflammasome signaling pathway induced by HPS, and observed the protective effect of BA on ROS generation and cell apoptosis, using fluorescence microscopy [4]."
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"In lipopolysaccharide (LPS)-induced inflammatory macrophages, however, BA inhibited the NLRP3 inflammasome and reduced inflammation."
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