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Barium(2+) inhibits NLRP3. 32 / 32
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"In addition, in vitro experiments confirmed that the key BA metabolites (mainly UDCA, DCA, and LCA) stimulated TGR5 signal to inhibit the assembly of the NLRP3 inflammasome and alleviated inflammation."
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"Mechanistically, BA repressed microglial pyroptosis, reduced inflammatory factor release, and attenuated neuronal injury by inhibiting the NLRP3/GSDMD pathway."
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"Conjointly, BA reduced microglial pyroptosis in hippocampal CA1 area by inhibiting the NLRP3/GSDMD pyroptosis pathway, thereby ameliorating post-SE neuronal injury in mice."
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"In this study, we found BA dramaticlly suppress the activation of the NLRP3 inflammasome."
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"In support of this, BA administration effectively suppressed the activation of NLRP3 inflammasome induced by LPS plus ATP, as evidenced by reduced expression levels of NLRP3, caspase-1 p20, and IL-1β (Fig. 5D and E)."
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"Nevertheless, whether BA can suppress the microglial NLRP3/GSDMD pyroptosis pathway and relieve post-SE neuronal injury in mice remains largely unknown."
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"BA repressed the activation of the NLRP3/GSDMD pyroptosis pathway and attenuated microglia pyroptosis after SE in mice."
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"To verify whether BA specifically inhibits NLRP3 inflammasome, we next tested the effect of BA on the AIM2 inflammasome and NLRC4 inflammasome."
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"Moreover, BA treatment effectively suppressed the activation of NLRP3 inflammasome in the liver of septic mice (Fig. S4G)."
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"Based on these results, BA suppressed the activation of NLRP3 inflammasomes by affecting NLRP3-dependent ASC oligomerization.Calcium influx is one of the most important upstream signaling pathways of [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"BA suppressed post-SE neuronal injury by inhibiting the NLRP3/GSDMD pyroptosis pathway in mice."
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"Baicalin (BA), a natural flavone, reduced hepatic NLRP3 inflammasome components, NLRP3 and caspase-1, which activate interleukins (IL), measured as IL-1."
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"The results showed that BA treatment inhibited the activation of the NLRP3 inflammasome in vivo and alleviated LPS-mediated inflammatory response.In order to further study the effect of BA on inflamma[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, BA suppresses the NLRP3/GSDMD pyroptosis pathway and alleviates microglia pyroptosis after SE in mice."
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"These results indicate that BA inhibits the NLRP3/GSDMD pyroptosis pathway and mitigates microglial pyroptosis after SE in mice."
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"To determine whether BA suppressed activation of the NLRP3 inflammasome by regulating calcium influx, LPS-primed BMDMs were treated with or without BA and then stimulated with ATP."
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"We previously showed that BA significantly inhibited the activation of NF-kappaB and the NLRP3 inflammasome during H. parasuis infection in piglet primary mononuclear phagocyte 34."
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"Our data demonstrate that BA effectively inhibits the activation of NLRP3 inflammasome in macrophages by targeting hnRNPA2B1."
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"The results showed that BA treatment inhibited the activation of the NLRP3 inflammasome, meanwhile, the Nrf2/HO-1 signaling pathway was activated."
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"In vitro studies, the activated NLRP3 inflammasome produces mature IL-1beta by facilitating the cleavage of pro-IL-1beta, and BA could inhibit the activation of NLRP3 inflammasome in BMDMs."
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"More importantly, in a rat model of sepsis cardiomyopathy, BA inhibited NF-κB and NLRP3 inflammatory activation to prevent myocardial injury and cardiac dysfunction."
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"Earlier studies by our group showed that BA can suppress the NLRP3 inflammasome pathway under LPS stimulation [11], and it also has anti-inflammatory activity via NF-κB and NLRP3 inflammasome signaling evoked by HPS in PMNP [4]."
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"In lipopolysaccharide (LPS)-induced inflammatory macrophages, however, BA inhibited the NLRP3 inflammasome and reduced inflammation."
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"BA Inhibited the Activation of NLRP3 Inflammasome in Macrophage."
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"Furthermore, we also found that BA could dose-dependently deactivate the activation of NLRP3 inflammsome in PMA-induced THP-1 macrophages (Figures 9(d) and 9(e))."
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"These results suggest that BA can inhibit the NLRP3 inflammasome and show an anti-inflammatory effect in inflammatory conditions."
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"In our earlier study, we demonstrated that BA could inhibit the activation of the NF-κB and NLRP3 inflammasome signaling pathway induced by HPS, and observed the protective effect of BA on ROS generation and cell apoptosis, using fluorescence microscopy [4]."
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"As previous studies suggested, BA can inhibit the activation of NLRP3 inflammasome via TGR5 signaling (Guo et al., 2016a)."
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"From our in vitro experiments, we found that BA treatment could dose-dependently deactivate the activation of the NLRP3 inflammasome, which reduces the activation of caspase-1."
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"These findings suggest that BA may inhibit the NLRP3 inflammasome.Autophagy-mediated modulation of the inflammasome has many complex functions (Harris et al., 2017)."
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"Antagonizing TGR5 with SBI-115 offsets the inhibitory effect of BA, especially DCA and CDCA, on IL-1β and NLRP3 to some extent (Figure 4D), indicating that TGR5 is involved in the inhibition of NLRP3 inflammasome by BA in inflammatory conditions."
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"Therefore, we speculate that the combination of MitA or other SP1 inhibitors and CPT-11 might achieve a startling effect of reducing the side effect and enhancing the anticancer efficacy simultaneously in the treatment of colorectal cancer.In inflammatory conditions, we show in this study that TGR5 participates in the inhibition of NLRP3 inflammasome by BA in vitro, while in vivo TGR5 was significantly promoted by OA, but not affected by CPT-11 and MitA treatments."
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