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Phosphatase inhibits USP7. 3 / 3
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"Here, we report that in response to DNA damage USP7 is downregulated by the ATM dependent protein phosphatase PPM1G, thus downregulating Mdm2 and activating the p53 response."
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"The authors demonstrated that USP7 degradation is initiated by the PPM1G protein phosphatase, which is activated by ATM dependent phosphorylation in response to DNA damage."
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"CK2 's stabilization of USP7 further contributes to MDM2 stabilization and downregulation of p53, and after ionizing radiation, the ATM dependent protein phosphatase PPM1G downregulates USP7, reversing its effects on MDM2 and p53 [XREF_BIBR]."
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