IndraLab

Statements


CD274 leads to the phosphorylation of PTPN6. 6 / 6
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reach
"PD-L1 induced the phosphorylation of SHP-1 in DRG TRPV1 neurons and inhibited TRPV1 currents."

reach
"The administration of PD-L1 to naive mice induces analgesia by activating PD-1 and downstream SHP-1 phosphorylation, leading to inhibition of the function of sodium channels and TRPV1, and enhancing the function of potassium channels (TREK2) in PSNs (138, 139, 142)."

sparser
"PD-L1 induced the phosphorylation of SHP-1 in DRG TRPV1 neurons and inhibited TRPV1 currents."

sparser
"Moreover, PD-L1-induced SHP-1 phosphorylation was blocked by SHP-1 inhibitor sodium stibogluconate (SSG) in dissociated DRG neurons ( xref )."

reach
"Furthermore, a study suggested that PD-L1 induced the phosphorylation of SHP-1 via PD-1 and dose-dependently suppressed TRPV1 currents in DRG neurons, participating in the inhibition of hyperalgesia [35]."

sparser
"Furthermore, a study suggested that PD-L1 induced the phosphorylation of SHP-1 via PD-1 and dose-dependently suppressed TRPV1 currents in DRG neurons, participating in the inhibition of hyperalgesia [ xref ]."