IndraLab

Statements

Celastrol inhibits IKBKB. 7 / 8
| 6 1
reach
"Inhibition of IKKbeta by celastrol and its analogues - an in silico and in vitro approach."
27931154
sparser
"Moreover, Lee et al. ( xref ) have reported that celastrol inhibited the constitutively active IKKβ without suppressing DNA binding of NF-κB. Collectively, celastrol was observed to prevent IκBα phosphorylation induced by different stimuli via targeting IKKβ, the common step in NF-κB activation pathways."
27931154
reach
"Celastrol is a quinone methide triterpene inhibiting directly kinases IKKalpha and IKKbeta and inactivates CDC37 (cell division cycle 37) and p23 (prostaglandin E synthase 3) proteins and is thus an HSP90 (heat-shock protein 90 kDa) inhibitor."
26775695
reach
"This study determines the neuroprotective and inhibitory effect of celastrol on amyloid beta 1-42 (Abeta 1-42) induced cytotoxicity and IKKbeta activity, respectively."
27931154
reach
"Celastrol is a natural triterpene used as a treatment for inflammatory conditions.Objective: This study determines the neuroprotective and inhibitory effect of celastrol on amyloid beta 1-42 (Abeta 1-42 ) induced cytotoxicity and IKKbeta activity, respectively.Materials and methods: Retinoic acid differentiated IMR-32 cells were treated with celastrol (1 muM) before treatment with Abeta 1-42 (IC 30 10 muM) for 24 h."
27931154
reach
"Celastrol inhibits Abeta 1-42 induced IKKbeta activity."
27931154
reach
"Inhibition of IKKbeta by celastrol and its analogues - an in silico and in vitro approach."
27931154