IndraLab

Statements

EZH2 inhibits BAP1. 3 / 3
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"Concomitant Bap1 and Ezh2 loss reduced myeloid progenitor expansion, reduced the proportion of Mac1 + Gr1 + myeloid cells, restored erythroid differentiation (CD71 + Ter119 +) and decreased proliferation of Bap1 and Ezh2 deficient progenitors (XREF_FIG and XREF_SUPPLEMENTARY)."
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"35 This is in line with our observations that EZH2 inhibition upregulates genes of the cholesterol and mevalonate biosynthesis pathways in BAP1-mutated settings with concomitant addiction to these pathways."
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"Ezh2 haploinsufficiency reduced, but did not abrogate, Bap1 deficient myeloproliferation (XREF_SUPPLEMENTARY) consistent with a dose dependent requirement for Ezh2."
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