IndraLab

Statements

SCN5A activates LQTS3. 3 / 3
| 3
reach
"40 Owing to initial concerns about the proarrhythmic effects of bradycardia and higher rate of breakthrough cardiac events, 41 patients with SCN5A mediated LQTS3 are typically treated more aggressively with implantable cardioverter-defibrillators (ICDs)."
32494476
reach
"However, most pathogenic variants are still identified in the three first described genes : KCNQ1, KCNH2, and SCN5A [XREF_BIBR, XREF_BIBR], causing LQTS1, LQTS2, and LQTS3, respectively."
33256261
reach
"XREF_BIBR, XREF_BIBR, XREF_BIBR Late I Na can be enhanced by congenital mutations in SCN5A that cause LQTS3, by SCN5A polymorphisms (Y1102 and Y1103), or by acquired cardiac pathologies such as heart failure, myocardial hypertrophy, and ischemia."
19084812