IndraLab

Statements


KCNK18 inhibits NRGN. 5 / 5
| 5

reach
"In 2 rate models of diabetes, we found that activation of the TRESK K+ channel reduced NG excitability and disrupted gastrointestinal functions."

reach
"Silencing the TRESK K + channel in the diabetic rat should restore NG excitability and improve gastrointestinal functions mediated by the vago-vagal reflex."

reach
"Silencing TRESK K + channels restores excitability of NG neurons of diabetic rats."

reach
"In vivo silencing of the TRESK K + channel restores NG responsiveness to peptide stimulation and normalizes gastrointestinal functions mediated by the vago-vagal reflex in diabetic rats."

reach
"Reducing expression of the TRESK K+ channel restored NG excitability in vitro and in vivo, as well as CCK8 stimulated secretion of pancreatic enzymes and secretin induced gastrointestinal motility, which are mediated by vagovagal reflexes."