IndraLab

Statements

KCNK18 inhibits NRGN. 5 / 5
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"In vivo silencing of the TRESK K + channel restores NG responsiveness to peptide stimulation and normalizes gastrointestinal functions mediated by the vago-vagal reflex in diabetic rats."
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"In 2 rate models of diabetes, we found that activation of the TRESK K+ channel reduced NG excitability and disrupted gastrointestinal functions."
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"Silencing TRESK K + channels restores excitability of NG neurons of diabetic rats."
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"Reducing expression of the TRESK K+ channel restored NG excitability in vitro and in vivo, as well as CCK8 stimulated secretion of pancreatic enzymes and secretin induced gastrointestinal motility, which are mediated by vagovagal reflexes."
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"Silencing the TRESK K + channel in the diabetic rat should restore NG excitability and improve gastrointestinal functions mediated by the vago-vagal reflex."
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