IndraLab

Statements

TP53 phosphorylated on S15 activates TP53. 4 / 4
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"Phosphorylation of p53 on Ser15, which occurs rapidly after DNA damage, could block ubiquitination and proteasome degradation of p53, which contributed to the overall stability of p53."
33613308
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"The Ser15 phosphorylation of p53 disrupts the interaction between p53 and Mdm2, and also enhances the transcription activity of p53 (Kapoor et al., 2000; Shieh et al., 1997; Siliciano et al., 1997)."
21163364
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"In the classical model, N-terminal phosphorylation of p53 at Ser 15 (mouse Ser 18) and Ser 20 (mouse Ser 23) inhibits the interaction with MDM2 and thereby prevents MDM2 mediated ubiquitination and the resulting proteasomal degradation of p53 [XREF_BIBR] (XREF_FIG)."
22675363
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"P53S15 phosphorylation is known to increase the transactivating function of p53 37 and thus may contribute to transcriptional activation of the bax gene 38 and apoptosis induction 21."
11602639