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USP9X deubiquitinates EGLN3. 2 / 3
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"In cholangiocarcinoma (CCA), the tumor suppressor KIF1Bβ induced apoptosis and was up-regulated by Egl nine homolog 3 (EGLN3), and ubiquitin-specific peptidase 9X (USP9X) acted to de-ubiquitinate and stabilize EGLN3 thereby accelerating this process."
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"USP9X exerts its tumor-suppressive functions through deubiquitinating Egl-9 family hypoxia inducible factor 3, thereby activating the apoptosis signaling pathway components, kinesin KIF1Bβ and cleaved caspase-3 (57)."
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