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STAT3 binds USP20. 5 / 5
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"We next performed validation of the mass spectrometry by immunoprecipitation and found that USP20 interacts with STAT3 in heart tissues and neonatal rat cardiomyocytes (NRCMs) following Ang II treatment (Figure  xref ), suggesting that USP20 directly binds to the STAT3 protein in cardiomyocytes."
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"By co‐transfecting STAT3 and the mutated USP20 plasmids into NIH3T3 cells, we found that USP20 could not bind to STAT3 when amino acids 791 to 894 were deleted, whereas mutations in other domains did not affect such binding (Figure  xref )."
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"In this research, we identified an unannotated cardiomyocyte‐specific USP20‐STAT3 axis, highlighting its role in regulation of cardiac hypertrophy ( Structured Graphical Abstract )."
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"We hypothesized that USP20‐STAT3 axis ameliorates cardiac hypertrophy through transcriptional regulation of Carm1 ."
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"We observed that the K177R mutation did not disrupt USP20‐STAT3 binding but resulted in significantly lower STAT3 ubiquitination compared to the wild‐type, and this reduction was not further decreased by USP20 overexpression (Figure  xref )."
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