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Quercetin inhibits STAT1. 24 / 25
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"In the flowers, quercetin and kaempferol can inhibit the signal transducer and activator of transcription 1 (STAT-1) and the NF- κ B pathways [ xref , xref ]."
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"These observation was consistent with the anti-inflammatory effects of some flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF- κ B activation, whereas flavone, isorhamne[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"[24] Hamalainen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. Anti-inflammatory effects of flavonoids : genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages."
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"In the flowers, quercetin and kaempferol can inhibit the signal transducer and activator of transcription 1 (STAT-1) and the NF-κB pathways [72,73]."
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"Furthermore, when used at 50 μM concentration, both resveratrol and quercetin abrogated basal IRF1 and P-STAT1 and prevented cetuximab- or gefitinib-driven enhancement of both these proteins (Figure 2C,D)."
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"Flavonoids such as apigenin, isorhamnetin, kaempferol, and quercetin have been shown to inhibit NF-κB and STAT-1 activation [ 167 , 168 ], and some of them also inhibit COX-2 expression [ 169 , 170 ]."
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"Quercetin effectively inhibits the shift of macrophages/microglia toward the M1 phenotype polarization by inhibiting the STAT1 and NF-κB pathways, resulting in reduced necroptosis of OLs [43]."
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"Flavonoids like genistein, kaempferol, quercetin, and daidzein inhibited STAT-1 and NF-kappa B activations in anti-inflammatory effects [XREF_BIBR]."
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"Daidzein, genistein, kaempferol, and quercetin also inhibited the STAT-1 pathway [54]."
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"Inhibition of STAT-1 activation by quercetin is likely involved in the mechanisms by which it inhibits iNOS expression because JAK inhibitors AG-490 and WHI-P154 have been shown to inhibit iNOS expression along with their suppressive actions on STAT-1 activation [XREF_BIBR, XREF_BIBR]."
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"Genistein, kaempferol, quercetin, and daidzein also inhibited the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS."
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"As kaempferol and quercetin have shown to inhibit the activation and production of STAT-1 and nuclear factor-κB (NF-κB) ( Pluemaj and Saifah, 1986 ), IL-1β along with iNOS expression and NO production[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Anti-Inflammatory Effects of Flavonoids : Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-kappaB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-kappaB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages."
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"In addition, genistein, kaempferol, quercetin, and daidzein also inhibited STAT-1 activation."
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"Fig. 3 D further showed that IFN-γ-elicited STAT1 activation, as assessed by EMSA, was inhibited by quercetin."
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"Then, Kim and Park [75], using a model of double-stranded (ds) RNA virus-induced macrophages, showed that quercetin significantly decreased the production of inflammatory mediators (IL-6, MCP-1, IP-10, RANTES, GM-CSF, G-CSF, TNF-α, LIF, LIX, and VEGF) and inflammatory signaling (STAT1 and STAT3) in RAW 264.7 macrophages."
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"Quercetin inhibits interleukin-1β (IL-1β), IL-6, and TNF-α, as well as STAT-1 and NF-κB (Hämäläinen et al., 2007)."
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"The mechanisms by which genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 activation are not known, but may be associated with inhibition of phosphorylation of STAT-1 or its up-stream kinase JAK2 [XREF_BIBR]."
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"twice daily for 10 days) also promoted microglia polarizing from M1 (labeled with Arg-1) to M2 (labeled with iNOS) phenotype through inhibition of STAT1 and NF-κB pathway in vivo and in vitro.164 Besides, quercetin (100 mg/kg, i.p."
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"The quercetin induced activation of STAT1 inhibited cell proliferation, which may lead to the observed potentiation of the IFN-alpha-induced antiproliferative effect in HepG2 and Huh7 cells."
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"Based on in vivo and in vitro investigations, quercetin (7.5 mg/kg) suppressed oligodendrocyte necroptosis after SCI by modulating the STAT1 and NF-κB pathways [107]."
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"It has been reported that quercetin inhibits the activation of IKK, NF-κB, STAT1, iNOS, NO, TNFα, MAPKs, Akt, Src, JAK-1 and Tyk2."
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"Thus, quercetin inhibits LPS-induced STAT-1 and has an inhibitory effect on iNOS expression and NF-kB activation."
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"Quercetin significantly inhibited p38 and the transcription signal activator 1 (STAT1) transducer and activator, which in turn inactivated NF-κB and inflammatory cytokines in the liver of nickel-treated mice."
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