IndraLab

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Sulforaphane inhibits JUN. 4 / 4
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"Nonetheless, it is noteworthy that, in addition to activating NRF2, sulforaphane inhibits the transcription factor activator protein-1 (AP1) in the skin of mice exposed to UVR [ xref ] and is also an inhibitor of transcription factor nuclear factor κB (NFκB) [ xref ]."
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"Furthermore, sulforaphane has been shown to attenuate LPS-induced activation of NF-κB and activator protein-1 (AP-1) [19] ."
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"Nonetheless, it is noteworthy that, in addition to activating NRF2, sulforaphane inhibits the transcription factor activator protein-1 (AP1) in the skin of mice exposed to UVR [185] and is also an inhibitor of transcription factor nuclear factor κB (NFκB) [187]."
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"In particular, SFN increased pro survival ERK (extracellular signal regulated kinase) and antiapoptotic p38beta mitogen activated protein kinase, and decreased the proapoptotic Jun N-terminal kinase (JNK) and p38alpha pathways."
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