IndraLab

Statements


ADAR ubiquitinates USP38. 6 / 6
| 6

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"ADAR promotes USP38 auto-deubiquitylation and stabilization in an RNA editing-independent manner in esophageal squamous cell carcinoma."

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"Mechanistically, ADAR interacts with USP38 to enhance USP38 protein stability and promote USP38 auto-deubiquitylation."

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"We asked whether ADAR also plays a role in the auto-deubiquitylation of USP38."

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"These results indicate that ADAR promotes the auto-deubiquitylation of USP38 and thereby stabilizes USP38 through interaction with USP38."

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"In this study, we demonstrate that ADAR enhances the auto-deubiquitylation and stabilization of USP38."

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"Mechanistically, we demonstrate that ADAR enhances USP38 auto-deubiquitylation to increase USP38 protein stability and upregulate USP38, thereby affecting cell proliferation and growth."