IndraLab

Statements

USP15 activates NFATC2. 4 / 5
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"NFATc2 also plays a crucial role peripherally, as the loss of the deubiquitinating enzyme USP15 indirectly inhibits NFATc2 degradation, promoting T cell activation [51]."
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"USP15 deficiency did not enhance Nfatc2 mRNA induction, as revealed by a qRT-PCR assay (XREF_SUPPLEMENTARY)."
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"Therefore, USP15 deficiency promotes NFATc2 activation, causes increased T cell responses and function in antitumor immunity."
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"USP15 deficiency enhances NFATc2 activation in naive CD4 + T cells."
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