IndraLab

Statements

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"Most interesting, a recent report (Bucchi et al., 2006) indicates that ivabradine blocks HCN1 in a use dependent manner via the closed state, but HCN4 via a voltage dependent, open state mechanism."
18162181
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"Ivabradine inhibits HCN1 either in the closed state or in a transitional state between closed and open, and the direction of current flow has little effect on block."
25911606
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"Nevertheless, it was interestingly shown that, on the contrary to HCN4 and native I f, ivabradine is able to block HCN1 in the closed state (Bucchi et al., 2006)."
20933199
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"53 However, the HCN1 antagonist ivabradine, approved in Europe for angina, does not cross the blood-brain barrier."
25869805
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"Properties of ivabradine induced block of HCN1 and HCN4 pacemaker channels."
16484306