IndraLab

Statements

Sertindole inhibits KCNH2. 5 / 14
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"Using patch clamp electrophysiology, we found sertindole blocked HERG currents with an IC50 value of 14.0 nM when tail currents at -40 mV were measured after a 2-sec depolarization to +20 mV."
9694935
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"Sertindole has been shown to inhibit HERG currents with an IC 50 value of 14 nM ( Rampe et al., 1998 )."
16647758
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"A study using the HERG blocker Sertindole showed that the T wave attained minimum height just before the onset of TdP [XREF_BIBR]."
26411977
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"Out of all the drugs tested, sertindole was able to block hERG channels with highest affinity in the low nanomolar range."
22565090
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"Pimozide and sertindole, for example, have previously been shown to block HERG in the low nanomolar range (Rampe et al., 1998; Kang et al., 2000)."
12176106