IndraLab

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TET1 demethylates USP28. 3 / 3
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"Collectively, our results demonstrate that ATG7 autophagic removal of AUF1 promotes tet1 mRNA stabilization, which demethylates usp28 promoter, and in turn resulting in accumulation of CD44s protein, finally promoting cancer stem like properties, invasion and lung metastatic activity of human high invasive BC cells as shown in XREF_FIG."
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"Ten-eleven translocation1 (Tet1), a DNA demethylase, can promote the expression of USP28 through facilitating demethylation of USP28 promoter."
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"Collectively, our results strongly demonstrate that ATG7 overexpression mediated TET1 upregulation contributes to usp28 promoter demethylation, thereby increasing USP28 expression, consequently resulting in CD44s protein accumulation, and finally enhancing BC stem sphere formation, invasion, and lung metastatic activity."
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