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Arachidonic acid inhibits FOS. 3 / 3
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"Some studies have indicated that arachidonic acid induces the activation of p38 MAPK/ATF-2 and the inhibition of ERK/c-Fos pathways, leading to increased Fas/FasL expression in U937 cells [26]."
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"Moreno et al. found that calcitriol abolishes c-fos induction and growth stimulation by arachidonic acid , which reflects the effect of calcitriol in decreasing endogenous synthesis of PGs due to COX-2 suppression in PCa cells [ 91 ] ."
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"Blocking the conversion of arachidonic acid to prostaglandins by inhibiting cyclooxygenase abolishes arachidonic acid induced accumulation of c-fos and Egr-1 mRNA."
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