IndraLab

Statements

USP2 binds CD47. 13 / 13
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"Mechanistically, USP2 interacts with CD47, stabilizing it through deubiquitination."
40379682
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"Mechanistically, USP2 interacts with CD47 and removes ubiquitination on CD47, leading to the stabilization of CD47 (Fig.  xref )."
40379682
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"Meanwhile, we observed a strong endogenous interaction between USP2 and CD47 in both PC9 and H1975 lung cancer cells (Fig.  xref )."
40379682
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"In this study, our findings reveal that USP2 interacts with CD47, facilitating the deubiquitination of CD47 and leading to the stabilization of the CD47 protein."
40379682
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"Collectively, these results demonstrate that USP2 interacts with CD47 in cells."
40379682
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"Considering USP2 as a deubiquitinating enzyme, we hypothesized that USP2 might interact with CD47 to erase the ubiquitination on CD47."
40379682
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"To further dissect the mechanism of how USP2 regulates the expression of CD47, we performed co-immunoprecipitation assays and found that USP2 interacted with CD47 ( xref , xref )."
41534899
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"CD47 mainly interacted with the N-terminal domain of USP2, but not with the C-terminal USP domain ( xref )."
41534899
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"The results demonstrated that the N-terminal domain, but not the C-terminal domain of USP2, interacted with CD47 (Fig.  xref )."
40379682
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"These findings identify the USP2-CD47 axis as a critical driver of tumor immune evasion and anti-PD-1 therapy resistance."
40379682
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"Moreover, no significant difference in the anti-tumor effects of ML364 & PD-1 mAb combination therapy was observed between the sg Control and sg Cd47 groups, suggesting that, in the mouse lung cancer model, the anti-tumor effect of ML364 combined with PD-1 mAb is primarily driven by the USP2-CD47 axis (Fig.  xref )."
40379682
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"USP2 interacts with CD47 and deubiquitinates CD47."
40379682
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"The GST pull-down assay showed that CD47-Δ3 with missing amino acid residues from 290 to 323, but not the CD47-Δ1 lacking the residues of 163–176 and Δ2 deleting residues of 229–235 in the cytoplasmic region, failed to interact with USP2 in cells, suggesting that CD47 interacts with USP2 largely through its C-terminal cytoplasmic region (Fig.  xref )."
40379682