IndraLab

Statements



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"In LPS stimulated macrophage like cell line J774.1, the knockdown of USP2 promoted cytokine production, whereas the ectopic expression of USP2 repressed cytokine production."

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"USP2a, a 69-kDa splice variant of USP2, also known as USP9 and UBP41, negatively regulates NF-kappaB activation and proinflammatory cytokine production by interacting with TRAF6."

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"In this study, we demonstrated that USP2KD promotes 25 of 104 cytokines in macrophage like cells after LPS stimulation, while ectopic expression of USP2 represses most cytokine production following this stimulation."