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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP2 inhibits cytokine production. 3 / 3

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"In LPS stimulated macrophage like cell line J774.1, the knockdown of USP2 promoted cytokine production, whereas the ectopic expression of USP2 repressed cytokine production."

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"USP2a, a 69-kDa splice variant of USP2, also known as USP9 and UBP41, negatively regulates NF-kappaB activation and proinflammatory cytokine production by interacting with TRAF6."

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"In this study, we demonstrated that USP2KD promotes 25 of 104 cytokines in macrophage like cells after LPS stimulation, while ectopic expression of USP2 represses most cytokine production following this stimulation."

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USP2 inhibits cytokine production. 3 / 3

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