IndraLab

Statements

KCNB1 binds RyR. 5 / 5
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"This suggests that Kv2.1 and RyR form clusters independent of one another."
24962901
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"Having demonstrated a spatial and functional association of Kv2.1, LTCCs, and RyRs in hippocampal neurons that could be reconstituted in HEK293T cells, we next investigated whether clustering by Kv2.1 influenced the Cav1.2-mediated LTCC activity."
31663850
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"Future studies will determine whether specific protein kinases and phosphatases associate with these unique Kv2.1:RyR assemblies in MSNs, and their role on regulating Kv2.1 in response to stimulation by dopaminergic, muscarinic and other modulatory signaling pathways crucial to regulating the physiology of MSNs."
24962901
sparser
"However, the spatial association of Kv2.1 with endogenous LTCCs and RyRs in brain neurons has not been determined."
31663850
sparser
"Together, our findings establish a functional interaction between Kv2.1, LTCCs, and RyRs, reveal a significant influence of Kv2.1 in shaping neuronal LTCC activity, and support a critical role for Kv2.1 in the generation of somatodendritic Ca 2+ signals."
31663850