IndraLab
Statements
USP47 inhibits DNA Damage. 2 / 2
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2
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"As DNA damage repair plays an essential role in the maintenance or generation of CML stem and progenitor cells XREF_BIBR, XREF_BIBR, we hypothesized that DNA damage induced by USP47 knockdown might be vital to CML stem and progenitor cells."
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"Phenolic compounds not only inhibited the 26S activity but also decreased the USP47 levels, which reduce the DNA damage repair rate during oxidative stress; in addition, the presence of DNA fragments, procaspase-3 and a decreased poly (ADP-ribose) polymerase also appeared as a result of the above conditions."