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KCNQ1 inhibits TCF4. 1 / 1
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"Furthermore, increased expression of KCNQ1 in neurons causes decreased action potential frequency, and it is partly through this mechanism that Transcription Factor 4 (TCF4), a strong candidate gene for schizophrenia, alters the intrinsic excitability of prefrontal neurons and this excitability deficit is reversed by KCNQ1 antagonists (Rannals et al 2014)."