IndraLab

Statements

COPS5 inhibits CTNNB1. 3 / 3
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"At the same time, we found that CSN5 also promotes the degradation of beta-catenin in SW480 cells, indicating that the effect of CSN5 on beta-catenin levels and associated Wnt signaling could be dicho[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Although this result could indicate that in SW480 cells CSN5 would promote the degradation of β-catenin through the APC/SCF β-TrCP1 /UPS pathway, it is unclear at this point whether this is the case, [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, JAB1 knockdown seemed to enhance the degradation of total β-catenin in COLO-320 cells, and β-catenin remained non-ubiquitinated in wild-type and JAB1-silenced COLO-320 cells."
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