IndraLab

Statements

LRP6 binds USP46. 6 / 6
| 1 5
sparser
"Because the association of the USP46 complex with LRP6 was enhanced in the presence of Wnt stimulation (Fig.  xref ), we tested whether the USP46 complex interacted with LRP6 receptor aggregates in signalosomes that could be readily detected in sucrose density gradients xref ."
37798301
reach
"It remains to be determined whether the USP46 complex binds LRP6 as a pre-formed trimer or whether it proceeds through stepwise recruitment of individual subunits."
37798301
sparser
"It remains to be determined whether the USP46 complex binds LRP6 as a pre-formed trimer or whether it proceeds through stepwise recruitment of individual subunits."
37798301
sparser
"Wnt signaling promotes the binding of the USP46 complex to the Wnt coreceptor LRP6 at the cell surface, stabilizing LRP6 on the cell surface."
39329019
sparser
"The binding of the USP46 complex to LRP6 is enhanced by Wnt stimulation."
37798301
sparser
"Given its effect on LRP6 levels, we explored whether the USP46 complex interacted with LRP6."
37798301