IndraLab

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ERBB2 increases the amount of COPS5. 13 / 16
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"Also, HER2 has been found to activate JAB1 expression through the v-akt murine thymoma viral oncogene homolog 1 (AKT)/β-catenin pathway [ 16 ]."
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"We also demonstrated that HER-2 and neu increased beta-catenin and TCF-mediated Jab1 expression via the AKT signaling pathway because chemical inhibitor or dominant negative mutant of AKT effectively attenuated the stimulatory action of HER-2 and neu."
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"HER-2 and neu transcriptionally activates Jab1 expression via the AKT and beta-catenin pathway in breast cancer cells."
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"In this study, we reported that expression of Jab1 was stimulated by HER-2 and neu oncogene via transcriptional activation."
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"Inversely, in breast cancer cell lines, HER2 transcriptionally increased Jab1 expression via AKT/β-catenin pathways, and HER2 inhibition decreased Jab1 expression [26,27]."
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"Inhibition of HER-2 and neu activity by Herceptin or AG825 significantly attenuated Jab1 expression in HER-2 and neu-overexpressing MDA-MB-453 cells."
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"The regulation of Jab1 expression by HER2 through the AKT pathway is of great interest, and further studies could strengthen our understanding on the role of Jab1 in the tumorigenic process."
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"HER-2 enhances Jab1/CSN5 expression through transcriptional activation in breast cancer ."
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"Similarly, HER-2 and neu was found to activate Jab1 and CSN5 expression through the AKT and bet-catenin pathway [XREF_BIBR]."
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"HER-2/neu directly activates Jab1/CSN5 promoter activity and upregulates Jab1/CSN5 mRNA expression through the AKT/β-catenin pathway in breast cancer cells ( Hsu et al., 2007 )."
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"HER-2 enhances Jab1 and COPS5 promoter activity and increases Jab1 and COPS5 expression through AKT and beta-catenin pathway."
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"In addition, ErbB2 has been reported to transcriptionally activate expression of the Wnt pathway target gene Jab1 via an Akt and beta-catenin pathway in breast cancer cells."
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"Taken together, our results suggest that HER-2 and neu transcriptionally activates Jab1 expression to promote proliferation of breast cancer cells."
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