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KCNH2 activates localization. 3 / 3
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"Moreover, overexpression of hERG1 in MG-63 cells also led to increased nuclear localization of NF-kappaB p65."
27076857
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"Immunoblots and confocal microscopy indicated increased plasma membrane localization of KCNH2 alpha-subunits in cells cotransfected with KCNQ1-WT plasmid, while total KCNH2 protein synthesis and KCNH2 glycosylation remained unaffected, which suggests a chaperone effect of KCNQ1-WT to enhance the membrane localization of KCNH2."
19959132
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"XREF_BIBR that HERG increases membrane localization of KCNQ1 in transfected CHO cells, we hypothesized that the " I HERG booster " effect mediated by KCNQ1 may be linked to an event during the biogenesis of the channel, rather than through regulation of HERG biophysical properties at the membrane."
20348026