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SMAD6 activates BAP1. 2 / 2
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"Recent biochemical and cell based studies have showed that UBE2O ubiquitinates SMAD6 during bone morphogenetic protein signaling, induces cytoplasmic sequestration of nuclear BAP1, and coordinates endosomal protein trafficking."

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"Recent biochemical and cell based studies have shown that UBE2O ubiquitinates SMAD6 during bone morphogenetic protein signaling (Zhang et al., 2013a), induces cytoplasmic sequestration of nuclear BAP1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"