IndraLab

Statements

Resveratrol inhibits KCNH2. 3 / 3
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"In XREF_FIG, application of 10 muM resveratrol and 1 muM fexofenadine rescued hERG tail current reduction in the presence of 10 muM BBR."
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"Resveratrol is able to rescue the trafficking inhibition of hERG and relieve the ER stress triggered by arsenic trioxide."
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"In this study, we demonstrated that 1) cav-1 participates in BBR induced hERG deficiency on cell surface; 2) residues Tyr652 and Phe656, essential components of hERG binding sites, mediate hERG surface expression inhibition by BBR incubation; and 3) fexofenadine and resveratrol can shorten APD of ventricular cardiomyocytes prolonged by BBR."
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