IndraLab

Statements

COPS5 decreases the amount of NCOR. 2 / 2
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"In COPS5 overexpressing tamoxifen resistant MCF7 clone # 3, RNAi mediated knockdown of GPS1 and CSN1 (two independent short hairpin RNAs (shRNAs)), CSN2 (one shRNA), COPS5 (two independent shRNAs) or CSN6 (two independent shRNAs) invariably caused induction of NCoR protein expression (XREF_FIG)."
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reach
"These data strongly suggest that loss of NCoR protein expression by COPS5 amplification and overexpression is a driver of mediating tamoxifen-resistance."
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