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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 decreases the amount of NCOR. 2 / 2

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"In COPS5 overexpressing tamoxifen resistant MCF7 clone # 3, RNAi mediated knockdown of GPS1 and CSN1 (two independent short hairpin RNAs (shRNAs)), CSN2 (one shRNA), COPS5 (two independent shRNAs) or CSN6 (two independent shRNAs) invariably caused induction of NCoR protein expression (XREF_FIG)."

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"These data strongly suggest that loss of NCoR protein expression by COPS5 amplification and overexpression is a driver of mediating tamoxifen-resistance."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...