IndraLab

Statements

TERT binds BAP1. 5 / 5
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sparser
"Shorter overall survival was associated with TERT mutations ( p  = 0.03, median 29.6 months for MT versus 52.6 months for WT) or BAP1 mutations ( p  = 0.02, median 28.7 months for MT versus not reached for WT)."
30334004
sparser
"The presence of BAP1 or TERT promoter mutations was associated with a significantly worse OS."
30334004
sparser
"An exploratory analysis was performed to investigate if acquired mutations in BAP1 or TERT were associated with MSKCC prognostic risk group or the presence of sarcomatoid features on histopathologic review."
30334004
sparser
"This was also the case for mutually exclusive alterations such as SETD2–CDKN2A (3p21–9p21) and TERT–BAP1 (5p15–3p21) (Fig.  xref and Supplementary Tables  xref – xref )."
36138075
sparser
"Emerging evidence (particularly for hepatocellular carcinoma) suggests that TERT could interact with BAP1 via the WNT/β-catenin signaling pathway, which is often activated in tumors with TERT overexpression."
39858033