IndraLab

Statements

USP8 binds CHMP5. 7 / 7
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"It was revealed that positive selection induces CHMP5-USP8 interaction, thereby maintaining CHMP5 protein stability."
38562929
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"Further studies show CHMP5 binds USP8 in CD69 + TCRβ hi DP cells but not in CD69 − TCRβ neg-lo DP cells, which have not undergone positive selection, suggesting that positive selection induces USP8-CHMP5 interaction, thus CHMP5 is deubiquitinated and stabilized, enabling CHMP5 to inhibit oxidation and degradation of Bcl-2, thereby promoting survival of positively selected thymocytes ( xref )."
38562929
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"Another study identified USP8 as a specific deubiquitinase for CHMP5 (a component of ESCRT complex) and revealed the involvement of CHMP5-USP8 complex in modulating the positive selection of thymocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31078284
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"Another study identified USP8 as a deubiquitinase for CHMP5, a component of the ESCRT complex, and uncovered the role of the CHMP5-USP8 complex in regulating thymic positive selection ( xref , xref )."
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"Further studies show CHMP5 binds USP8 in CD69 TCRβ DP cells but not in CD69 TCRβ DP cells, which have not undergone positive selection, suggesting that positive selection induces USP8-CHMP5 interaction, thus CHMP5 is deubiquitinated and stabilized, enabling CHMP5 to inhibit oxidation and degradation of Bcl-2, thereby promoting survival of positively selected thymocytes (105)."
38562929
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"USP8 interacts with and stabilizes CHMP5, an ESCRT (endosomal-sorting complex-required-for-transport) protein required for thymocyte postselection survival and maturation."
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"Another study identified USP8 as a specific deubiquitinase for CHMP5 (a component of ESCRT complex) and revealed the involvement of CHMP5-USP8 complex in modulating the positive selection of thymocyte[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31078284