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USP10 increases the amount of BECN1. 2 / 3

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"In addition, USP10 increases the expression of BECN1 and VPS34 proteins."

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"For instance, IU1-47 (USP14 inhibitor) promotes autophagic flux in neuroglioma cells [229], and spautin-1 (USP10 and USP13 inhibitor) combines with metformin to decrease BRCA1 metabolism and proliferation by increasing the Beclin1 ubiquitination level to inhibit the cell autophagy process [230]."

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USP10 increases the amount of BECN1. 2 / 3

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