IndraLab

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USP14 activates proteolysis. 21 / 22
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"Usp14 activity antagonizes protein degradation."
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"The ability of USP14 to prevail over the proteasome in a kinetic competition may explain the suppression of protein degradation by USP14 's deubiquitinating activity 3."
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"The RNAi of UCHL5 or USP14 alone does not affect cell growth and proteasome composition but accelerates cellular protein degradation; however, RNAi of both UCHL5 and USP14 can inhibit cellular protein degradation."
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"RNAi of both Uch37 and Usp14 also had no effect on proteasome structure or proteolytic capacity, but inhibited cellular protein degradation."
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"Indeed, an inhibitor of the deubiquitinating enzyme Usp14 enhances proteasomal protein degradation and leads to the clearance of protein aggregates in human cells [XREF_BIBR]."
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"Thus, therapeutic inhibition of USP14 may promote protein degradation through UPS and autophagy pathways simultaneously."
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"We found that a selective small-molecule inhibitor of USP14 stimulates protein degradation in vitro and in cells, and also attenuates toxic effects of oxidatively damaged proteins."
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"Meanwhile, we found that USP14 selectively suppressed NLRP3 protein degradation through the USP motif on the NACHT domain in mediating inflammasome activation."
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"Proteomics analysis revealed that TGT may produce reproductive toxicity by affecting protein digestion and absorption, PPAR signaling pathway, PI3K-Akt signaling pathway, and other pathways."
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"We also found enhanced expression of transcripts encoding two ubiquitin specific proteases, including USP14 that suppresses protein degradation through deubiquitination of proteasome substrates, non catalytic inhibition of proteasome activity, and by regulating autophagy."
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"Biallelic USP14 variants in NDD patients perturbed protein degradation pathways, potentially contributing to disorder etiology."
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"The half-life of endogenous XPO1 protein was markedly shortened on account of USP14 knockdown (Fig. 4D), indicating that XPO1 protein degradation was stimulated by USP14 deficiency."
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"Unexpectedly, it turns out that Usp14/Ubp6 antagonize protein degradation and Rpn11 in particular [ 2–4 ]."
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"Thus, Usp14 and Ubp6 appears to suppress protein degradation through three mechanisms : deubiquitination of proteasome substrates, the " noncatalytic effect, " which operates directly on the proteasom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP14 inhibition both by either drug like IU1 or siRNA silencing has been confirmed to accelerate protein degradation XREF_BIBR XREF_BIBR, which has also been confirmed in this report; USP14 silencing also affected CuPT induced GFPu protein degradation."
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"Also in line with this principal, a specific chemical inhibitor of USP14 has recently been shown to enhance the rate of protein degradation ( Lee et al., 2010 )."
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"USP14 interacted with NLRP3 and inhibited NLRP3 protein degradation in EPC."
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"Conversely, USP14 might also activate proteolysis by degrading ubiquitin chains on target proteins and thereby enhance gate opening of the 20S proteasome."
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"Knockdown of USP14 accelerated protein degradation of TNF-α in LPS-stimulated RAW264.7 cells [12]."
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"SiRNA interference studies on the three DUBs in cancer cells suggested that RNAi of USP14 can inhibit cellular protein degradation [XREF_BIBR]."
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"Conversely, USP14 might also activate proteolysis by degrading ubiquitin chains on target proteins and thereby enhance gate opening of the 20S proteasome ( xref )."
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