IndraLab

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USP14 activates proteolysis. 13 / 14
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"Indeed, an inhibitor of the deubiquitinating enzyme Usp14 enhances proteasomal protein degradation and leads to the clearance of protein aggregates in human cells [XREF_BIBR]."
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"USP14 inhibition both by either drug like IU1 or siRNA silencing has been confirmed to accelerate protein degradation XREF_BIBR XREF_BIBR, which has also been confirmed in this report; USP14 silencing also affected CuPT induced GFPu protein degradation."
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"Thus, therapeutic inhibition of USP14 may promote protein degradation through UPS and autophagy pathways simultaneously."
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"We also found enhanced expression of transcripts encoding two ubiquitin specific proteases, including USP14 that suppresses protein degradation through deubiquitination of proteasome substrates, non catalytic inhibition of proteasome activity, and by regulating autophagy."
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"The RNAi of UCHL5 or USP14 alone does not affect cell growth and proteasome composition but accelerates cellular protein degradation; however, RNAi of both UCHL5 and USP14 can inhibit cellular protein degradation."
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"The ability of USP14 to prevail over the proteasome in a kinetic competition may explain the suppression of protein degradation by USP14 's deubiquitinating activity 3."
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"RNAi of both Uch37 and Usp14 also had no effect on proteasome structure or proteolytic capacity, but inhibited cellular protein degradation."
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"Conversely, USP14 might also activate proteolysis by degrading ubiquitin chains on target proteins and thereby enhance gate opening of the 20S proteasome ( xref )."
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"SiRNA interference studies on the three DUBs in cancer cells suggested that RNAi of USP14 can inhibit cellular protein degradation [XREF_BIBR]."
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"Thus, Usp14 and Ubp6 appears to suppress protein degradation through three mechanisms : deubiquitination of proteasome substrates, the " noncatalytic effect, " which operates directly on the proteasom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Usp14 activity antagonizes protein degradation."
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"We found that a selective small-molecule inhibitor of USP14 stimulates protein degradation in vitro and in cells, and also attenuates toxic effects of oxidatively damaged proteins."
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"Conversely, USP14 might also activate proteolysis by degrading ubiquitin chains on target proteins and thereby enhance gate opening of the 20S proteasome."
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