IndraLab

Statements

Emodepside activates KCNMA1. 6 / 6
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"Electrophysiological studies on Ascaris suum are consistent with emodepside activation of SLO-1, but with a slow time course, possibly indicative of a non extracellular binding site within the transmembrane domains [XREF_BIBR]."
25554739
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"The response to BK channel activation by emodepside in other tissues may show less sensitivity and hence little side effects due to their unique physiological requirements and activation threshold or even differences in isoforms."
39817180
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"Intriguingly we found that emodepside modulated nematode (Ce slo-1), insect (Drosophila, Dm slo) and human (hum kcnma1) SLO channels but that there are discrete differences in the features of the modulation that are consistent with its anthelmintic efficacy."
26437177
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"XREF_BIBR proposed that emodepside either directly or indirectly activates SLO-1 that is present in body wall muscle and motor neurons to produce its inhibitory effects in nematodes."
21910990
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"The prevailing view is that emodepside directly or indirectly activates SLO-1 XREF_BIBR, XREF_BIBR."
21490955
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"Thus in the presence of low intracellular Ca 2+ (52 nM) where the Dm Slo channel was closed at most voltages and also at higher intracellular Ca 2+ (e.g. 290nM) where the Dm Slo channel shows outward rectification, emodepside consistently induced a linear current-voltage behaviour of the Dm Slo channel (XREF_FIG) indicating a reduction in the rectifying properties of the channel without any shift in reversal potential."
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