IndraLab

Statements

FOXM1 binds USP22. 14 / 14
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"These results indicate that FoxM1 physically interacts with USP22 in breast cancer cells."
37398311
sparser
"Indeed, USP22 interaction with FoxM1 was detected in HEK-293T cells transiently transfected with Myc-USP22 and Flag-FoxM1 but not in control cells transfected with Flag-FoxM1 or Myc-USP22 alone ( xref C)."
39246448
sparser
"Our data indicate physical interaction between USP22 and FoxM1 is required for USP22-mediated suppression of FoxM1 ubiquitination, because mutation of cystines 61 and 63, which disrupts the zinc finger structure and its interaction with FoxM1 ( xref ), totally abolished USP22 activity in suppressing FoxM1 ubiquitination ( xref )."
37398311
sparser
"The endogenous interaction between USP22 and FoxM1 was further validated in patient-derived breast cancer L2G + TN1 and 4T1 cells ( xref D and xref B)."
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reach
"Indeed, USP22 interaction with FoxM1 was detected in HEK-293T cells transiently transfected Myc-USP22 and Flag-FoxM1, but not in control cells transfected with Flag-FoxM1 or Myc-USP22 alone (Fig. 3C)."
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reach
"The endogenous interaction between USP22 and FoxM1 in patient-derived breast cancer L2G TN1 cells was further validated (Fig. 3D and s3B)."
37398311
sparser
"Truncated mutation analysis revealed that the zinc finger-containing N-terminus is sufficient for USP22 interaction with FoxM1, while the C-terminus ubiquitin-specific peptidase domain is not involved in mediating its FoxM1 interaction ( xref F)."
39246448
reach
"Our data indicate physical interaction between USP22 and FoxM1 is required for USP22-mediated suppression of FoxM1 ubiquitination, because mutation of cystines 61 and 63, which disrupts the zinc finger structure and its interaction with FoxM1 (Fig. 3I), totally abolished USP22 activity in suppressing FoxM1 ubiquitination (Fig. 3G)."
37398311
sparser
"These results indicate that FoxM1 physically interacts with USP22 in breast cancer cells."
39246448
reach
"Indeed, USP22 interaction with FoxM1 was detected in HEK-293T cells transiently transfected with Myc-USP22 and Flag-FoxM1 but not in control cells transfected with Flag-FoxM1 or Myc-USP22 alone (Figure 3C)."
39246448
reach
"The endogenous interaction between USP22 and FoxM1 was further validated in patient-derived breast cancer L2G TN1 and 4T1 cells (Figures 3D and S3B)."
39246448
sparser
"Indeed, USP22 interaction with FoxM1 was detected in HEK-293T cells transiently transfected Myc-USP22 and Flag-FoxM1, but not in control cells transfected with Flag-FoxM1 or Myc-USP22 alone ( xref )."
37398311
sparser
"The endogenous interaction between USP22 and FoxM1 in patient-derived breast cancer L2G + TN1 cells was further validated ( xref and s3B)."
37398311
sparser
"Truncated mutation analysis revealed that the zinc finger-containing N-terminus is sufficient for USP22 interaction with FoxM1, while the C-terminus ubiquitin-specific peptidase domain is not involved in mediating its FoxM1 interaction ( xref )."
37398311