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USP14 inhibits PINK1. 2 / 2
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"Here, we report that genetic and pharmacological inhibition of USP14 promotes mitophagy, which occurs in the absence of the well characterised mediators of mitophagy, PINK1 and Parkin."
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"Since USP14 inhibition promotes PINK1/Parkin-mediated mitophagy [26], and USP14 modulates the degradation of tyrosine hydroxylase [27], the rate-limiting enzyme in dopamine biosynthesis, we hypothesize that USP14 may be related to PD."
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