IndraLab

Statements


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"Another autoantibody that has been detected in 4 patients with PERM is against dipeptidyl-peptidase - like protein (DPPX), a regulatory subunit of neuronal Kv4.2 potassium channel complex responsible for transient inhibitory currents that regulate repetitive firing rates into neuronal dendrites [ xref , xref ] (Fig.  xref )."

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"Protein expression of potassium voltage-gated channel subfamily D member 2 (Kv4.2) and potassium channel interacting protein 3 (KChIP3) was assessed by immunohistochemistry (IHC) and Western blot."

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"DPPX is a regulatory subunit of the Kv4.2 potassium channel complex expressed in neuronal dendrites and soma, and associates with the channels’ pore-forming subunits ( Kim et al., 2008 )."