IndraLab

Statements

USP18 inhibits RELA. 3 / 3
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"Here, we found that ectopic expression of USP18 suppressed nuclear accumulation of p65 as well as NF-kappaB activation by LPS treatment."
26240016
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"A different study involving various in vitro cancer models provides evidence that USP18-mediated p65/p50 inhibition causes inhibited proliferation and increased apoptosis in leukemia, multiple myeloma, B-cell lymphoma, and cervical cancer cells (42)."
39507445
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"Consistent with these results, we found that knockdown of USP18 enhanced NF-kappaB-luc activity induced by TNF-alpha, LPS, MyD88, TRAF6, TAK1-TAB1, IKKbeta, but not p65 (XREF_FIG)."
26240016