IndraLab

Statements

reach
"Expression of a catalytically active UCH-L1 promoted the proliferation of a UCH-L1-negative EBV transformed lymphoblastoid cell line (LCL) and inhibited cell adhesion, whereas a catalytic mutant had no effect, confirming the requirement of UCH-L1 enzymatic activity for the regulation of these phenotypes."
20187292
reach
"It is possible that a chemical modulator of UCH-L1 could lead to candidate therapeutics for PD, although whether the reduced hydrolase activity of UCH-L1 plays a role in the pathogenesis of PD is curr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20144674
reach
"Here we show that knockdown of UCH-L1 by RNAi inhibits the proliferation of BL cells in suspension and semisolid agar and activates strong LFA-1-dependent homotypic adhesion."
20187292