IndraLab

Statements

ATXN2 inhibits mutated ATXN3. 3 / 3
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reach
"Re-establishment of ataxin-2 levels reduces mutant ataxin-3 and alleviates Machado-Joseph disease pathogenesis opening a new avenue for therapeutic intervention in this and potentially other polyQ disorders."
26490332
reach
"Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease."
26490332
reach
"In light of this, it was shown that ATXN2 expression downregulates mutant ataxin-3 and mitigates the disease-associated symptoms in Machado-Joseph disease/Spinocerebellar ataxia type 3 (MJD/SCA3) mice models, while the overexpression of PABPC1 (the gene encoding PABP-1) or the ablation of the PAM2 domain in the ATXN2 protein do not produce such effects."
38877004