IndraLab

"Also, the interaction between deubiquitinated enzyme USP15 and SQSTM1, and ubiquitinated level of SQSTM1 were determined by Co-IP assay."

"Also, the interaction between deubiquitinated enzyme USP15 and SQSTM1, and ubiquitinated level of SQSTM1 were determined by Co-IP assay."

"For example, USP15 can deubiquitinate and stabilize the murine double minute 2 (MDM2) protein to hinder cancer cell survival, xref and it can deubiquitinate and suppress the activation of the ten-eleven translocation 2 (TET2) protein, thereby diminishing tumor immunogenicity. xref Additionally, USP15 can interact with sequestosome−1 (SQSTM1) to abolish the activation of ring finger protein 26 (RNF26), facilitating the release of diverse vesicles for fast transport and utilization of intracellular substances. xref A recent study has indicated an elevated expression of USP15 in HCC tumor tissues, revealing a close association with metastasis and poor prognosis. xref Thus, gaining a thorough understanding of this crucial modification implicated in the regulation of HCC progression could offer novel perspectives for cancer therapeutics."