IndraLab

Statements

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"USP22 silencing suppresses in vitro GC cell migration and invasiveness."
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"Liu et al. reported that USP22 promoted GC progression through the activation of c-Myc / NAMPT / SIRT1-dependent FOXO1 and YAP signaling pathways [ 32 ] ."
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"USP22 knockdown significantly decreased in vitro survival, proliferation, migration, and invasiveness of GC cells compared with the controls."
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"In this study, we show that USP22 knockdown significantly decreases migration and invasiveness of GC cells."
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"Meanwhile, USP22 is reported to promote GC distant metastasis (9, 10, 23)."
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"USP22 silencing inhibits GC cells proliferation."
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"These results suggest that USP22 promotes in vitro GC cell migration and invasion."
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"USP22 promotes in vitro GC progression by modulating c-Myc/NAMPT/SIRT1- dependent FOXO1 and YAP signaling pathways."
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"Meanwhile, the colony formation assays of MGC-803 cells also revealed that USP22 knockdown suppressed the proliferative ability of GC cells."
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"Liu et al. reported that USP22 promoted GC progression through the activation of c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling pathways [32]."
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"USP22 knockdown inhibits GC cell proliferation in vitro."
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"In this study, we demonstrated that USP22 mediated protein stabilization of BMI1 promotes gastric CSC stemness maintenance and GC progression, thereby providing a rationale for USP22 targeting as a potential therapeutic approach against GC."
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"We then investigated the mechanism by which USP22 drives GC progression by analyzing the status of various signaling pathways in the USP22-silenced and control GC cells."
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"Overall, these results indicate that USP22 promotes GC progression via c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.Our study has several limitations."
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"The mechanistic details regarding how USP22 promotes proliferation and survival in GC cells requires further in depth study."
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"USP22 promotes GC progression by modulating FOXO1 or YAP signaling pathways via c-Myc/NAMPT/SIRT1."
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"To generate mir-4490 and USP22-co-expressing cells, 3ml of a concentrated USP22 lentiviral expression vector solution was added to miR-4490 overexpressing GC cells as described previously."
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"MiR-4490 regulates USP22 mediated GC growth and metastasis in vivo."
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"These data suggest that USP22 promotes GC progression by modulating c-Myc/NAMPT/ SIRT1-dependent FOXO1 and YAP signaling."
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"USP22 depletion attenuates in vivo GC growth and metastasis."
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"These data demonstrate that USP22 promotes in vivo GC growth and metastasis."
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"USP22 knockdown decreases in vitro proliferation, migration and invasiveness of GC cells."
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