IndraLab

Statements

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"Consistently, knockout or pharmacological inhibition of USP13 impeded tumor cell proliferation and enhanced sensitivity to chemotherapeutic agents in both cell lines and mouse models (Han et al., 2016; Zhang et al., 2018)."
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"Inhibition of the phosphorylation of USP13 downregulated USP13 protein stability and reduced the proliferation of ovarian cancer cells, which may lead to novel therapeutics targeting USP13 in USP13-amplified cancers."
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"These results demonstrate that USP13 indirectly activates the Akt/mTOR pathway through WWP1.CCK-8 and colony formation assays revealed that WWP1 rescued the suppression of HCC cell proliferation caused by USP13 silencing (Fig. 5C, D)."
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"Our results indicate that spautin-1 as well as knockdown of its downstream targets, USP10 and USP13, reduced the proliferation and migration of glioblastoma cells."
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"Conversely, WWP1 knockdown reduced the increase in cell proliferation, migration, and stemness induced by USP13 overexpression (Supplementary Fig. S4C–I)."
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"Stable knockdown (KD) of USP13 by lentiviral short hairpin RNAs (shRNAs) markedly inhibited the proliferation of the USP13 amplified cell lines (CAOV3 and HeyA8) and the USP13 overexpressing cell line (OVCAR8)."
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"USP13 promotes the proliferation of small cell lung cancer (SCLC) (44)."
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"Ectopically expressed K488R of METTL3 significantly promoted cell proliferation and glycolysis, while USP13 knockdown decreased cell proliferation and glycolysis with WT METTL3 rather than K488R METTL3, which indicated that mutation of K488 of METTL3 promoted cell proliferation and glycolysis and abolished USP13 depletion-induced proliferation and glycolysis suppression (Fig. 4i-n)."
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"USP13 has been shown to upregulate fatty acid synthase (FASN) to promote the proliferation of SCLC cells and Twist-related protein 1 (Twist1) to promote the migration and invasion of breast cancer cells, while it inhibits cell proliferation via downregulation of glycolysis in oral squamous cell carcinoma (47,48)."
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"CCK-8 (Supplementary Fig. S5B) and colony formation assays (Supplementary Fig. S5C, D) revealed that Rapa significantly weakened the increase in cell proliferation induced by USP13."
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"USP13 signaling in cell proliferation and apoptosis."
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"USP13 promotes the proliferation of squamous cell lung carcinoma cells through AKT/MAPK signaling."
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"As revealed by the CCK-8 (Supplementary Fig. S2C, D) and colony formation (Supplementary Fig. S2E) assays, USP13 overexpression enhanced HCC cell proliferation."
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"Furthermore, re-expression of cyclin D1 partially reversed the cell cycle arrest and cell proliferation inhibition induced by USP13 depletion in GC cells."
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"Thus, the depletion of USP13 decreases ZHX2 and inhibits the proliferation of ccRCC (68)."
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"USP13 knockdown inhibits cell cycle progression and cell proliferation in GC."
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"USP13 overexpression promotes cell cycle progression and cell proliferation in a DUB enzyme activity dependent manner."
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"For example, USP13 stimulates melanoma cell invasion,20 drives ovarian cancer metabolism,21 and promotes the proliferation of glioma stem cells,22 which demonstrates the oncogenic roles of USP13 in these cancers."
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"USP13 promotes acute myeloid leukemia cell proliferation and autophagy by promoting ATG5."
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"Similarly, our results showed that depletion of USP13 by single guide RNAs also inhibited cell proliferation and colony growth (SI Appendix, Fig. S4 J and K and Fig. 3 K and L)."
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"In addition, USP13 promotes ccRCC cell proliferation in an enzymatic-dependent manner."
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"Furthermore, to determine how USP13 depletion leads to decreased ccRCC cell proliferation, we examined the apoptosis rate of ccRCC cells in these cells."
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"By contrast, USP13 expression induced by hypoxia activates TLR4/MYD88/NF-κB signaling and promotes cell proliferation (81)."
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"The elevated expression of USP13 promotes the cell cycle progression and cell proliferation by maintaining the stability of cyclin D1."
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"Next, USP13 knockdown prominently reduced the proliferation, epithelial-mesenchymal transition (EMT), migration, and invasion of Hep3B and Huh7 cells, while USP13 overexpression enhanced these biological behaviors of HepG2 and LO2 cells."
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"These results suggest that knockout of USP13 inhibits the proliferation of HCC cells.3.3 Overexpression of USP13 Facilitates the Proliferation of HCC Cells."
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"In addition, USP13 disruption significantly reduced GSC proliferation (XREF_FIG) but showed little effects on NSTCs and NPCs (not depicted)."
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"Moreover, silencing USP13 decreased cell proliferation in lung metastasis of hepatocellular carcinoma (34) and its overexpression is correlated with poor prognosis and chemoresistance of ovarian cancer (35)."
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"These results above indicate that elevated USP13 expression in HCC promotes cellular proliferation."
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"To confirm USP13 accelerates the proliferation of HCC cells through regulating PRPF6‐AKT‐mTOR signalling, we performed the rescue experiments by silencing PRPF6 in USP13 up‐regulated cells."
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"Interestingly, despite the fact that the viral oncogenes do not regulate USP13 expression, depletion of USP13 in HPV- C33A cells did not cause a proliferation defect."
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"In lung and ovarian cancers, where USP13 also regulates Mcl-1 stability, USP13 does not contribute to the cell proliferation of unstressed cells."
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"Furthermore, enhanced USP13 expression can stimulate MM cell proliferation both in vitro and in vivo."
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"Further studies will be required to identify these targets and understand how they contribute to USP13 mediated cell proliferation."
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"In order to clarify the mechanism by which USP13 promotes MM proliferation, we planned to conduct MS analysis on ARP1 WT and USP13‐OE cells."
40151951
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"These results suggest that the USP13‐PRPF6 axis promotes HCC cell proliferation by regulating AKT‐mTOR signalling.3.6 USP13 Expression Is Correlated With PRPF6 in Human HCC Tissues."
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"Therefore, we hypothesized that USP13/PARP1 may enhance MM cell proliferation by mediating DDR."
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"Further experimental results confirmed that the USP13‐PRPF6 axis promoted the proliferation of HCC cells by modulating the AKT‐mTOR signalling pathway.In conclusion, we have demonstrated that USP13 can decrease the K48/63‐linked polyubiquitination of PRPF6, thereby stabilising this protein and promoting HCC cell proliferation via regulation of the AKT‐mTOR pathway (Figure 8C)."
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"CK2-Mediated Phosphorylation Upregulates the Stability of USP13 and Promotes Ovarian Cancer Cell Proliferation."
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"In present study, we found that USP13 promotes glycolysis and progression in OS.To further explore the underlying mechanisms and protein-protein interactions by which USP13 promotes proliferation and metastasis of OS cells, IP/MS was performed and METTL3 was identified as a putative protein that binds to USP13."
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"XREF_FIG, USP13 deficiency significantly increased fibroblast proliferation."
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"In addition, we showed that USP13 depletion led to decreased cell proliferation and 2D colony growth as well as 3D anchorage–independent growth in ccRCC."
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"Further investigation revealed that the knockout of USP13 inhibited HCC cell proliferation, whereas overexpression of USP13 had the opposite effect."
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"Two independent USP13 shRNAs (XREF_FIG) both markedly increased the proliferation (XREF_FIG) and anchorage independent growth (XREF_FIG) of SUM159 breast cancer cells, while restoration of PTEN (XREF_FIG) or expression of an RNAi resistant USP13 mutant (XREF_SUPPLEMENTARY) completely reversed the effect of USP13 shRNA (XREF_FIG)."
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"After identifying oncogenic USP13 as a potential therapeutic target for BA and understanding how it contributes to MM progression, we conducted further research to determine if BA could inhibit MM cell proliferation induced by USP13."
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"USP13 promotes glycolysis and cell proliferation in OS."
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"Thus, USP13 deficiency suppressed HCC cell proliferation, migration, and stemness in vitro.To further validate the function of USP13 in HCC, we established USP13-overexpressing HCC cells via lentivirus (Supplementary Fig. S2A, B)."
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"Downregulation of USP13 resulted in reduced WISP1 protein stability, decreased cell proliferation, migration, and EMT, and increased apoptosis in vitro."
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"Also, EdU as well as colony-formation assays further confirmed downregulating USP13 suppressed cell proliferation whereas upregulation of USP13 significantly promoted cell proliferation in OS cells (Fig. 1c, d and S2c, d)."
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"The wild-type USP13 and phospho-mutant T122A increased cell proliferation compared to the mock sample in HeyA8 and COV318 cell lines (Figure 7A,B)."
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